Endocrine Abstracts

Background: Assessment of response to therapy is a valid tool for dynamic risk stratification in patients with differentiated thyroid cancer (DTC). It is well documented in patients treated with total thyroidectomy and radioiodine ablation therapy (RAI), but data is still sparse regarding patients treated with lobectomy. Our study aimed to evaluate response to therapy in patients with DTC treated with lobectomy.Methods: We performed a retrospective study...

Introduction: Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (pHPT) and has been traditionally performed through bilateral neck exploration (BNE). However, with the use of intraoperative parathyroid hormone (IOPTH) assay along with preoperative localization exams, minimally invasive surgery can be performed with good surgical success rate.Aim: To evaluate the usefulness of IOPTH assay in guiding adequate parathyroidectom...

Introduction: Hypoparathyroidism (hypoPTH) is one of the most feared iatrogenic complications of the surgical treatment for thyroid cancer (TC). Despite supplementation with calcium salts and calcitriol, hypoPTH seems to be associated with a negative impact on quality of life (QoL), which has not been evaluated in the Portuguese patients.Objectives: To evaluate the impact of hypoPTH on the QoL of Portuguese patients with TC and its correlation with serum...

Introduction: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor (1-2% of all thyroid carcinomas), which arises from calcitonin-producing C cells. Calcitonin (CT) and carcinoembryonic antigen (CEA) are used as tumor markers in the follow-up of patients with MTC. Non-secretory forms of MTC are very rare, accounting for less than 1% of the cases.Case Report: A 53-year-old man underwent left thyroid lobectomy for a 1.1 cm thyroid nodule subjec...

Introduction: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with poor prognosis. Objective: The aim of this study is to characterize patients with ACC followed at a tertiary center. Material and Methods: Retrospective analysis of clinical records of patients with histopathological diagnosis of ACC followed in our clinic. Results and conclusions: We reviewed 11 patients. The average age at diagnosis was 57.3±15.2 years and 63.6% were females. Seven patients...

Introduction: Primary hyperparathyroidism (pHPT) is the most common cause of hypercalcemia in the outpatient setting and is a frequent endocrine disorder. Large cohort studies of pHPT patients in the Portuguese population are scarce. Aim: To characterize patients with pHPT followed at a tertiary center.Material and Methods: Retrospective analysis of clinical records of patients with pHPT followed in our hospital from 2003 to 2021. ...

Introduction: Multiple endocrine neoplasia type 1 syndrome (MEN1) is a hereditary autosomal dominant disorder caused by germline mutations in the MEN1 tumour-suppressor gene and is typically characterized by parathyroid adenomas, duodenopancreatic neuroendocrine tumors (NETs) and pituitary adenomas. Breast cancer has recently been identified as manifestation of MEN1 and female patients have early onset elevated breast cancer risk.Case report: Female pati...

Introduction: Regional lymph node (LN) metastases have prognostic significance in differentiated thyroid cancer (DTC). Several studies demonstrated that lateral neck LN metastasis, classified as N1b, have a greater impact on overall survival than central LN metastasis. Our study aimed to assess the risk of N1a vs N1b involvement on outcome in patients with differentiated thyroid cancer (DTC), according to the 7th edition of the TNM staging system.Methods...

Introduction: Hypoparathyroidism is characterized by hypocalcemia and low or inappropriately normal levels of PTH. The most common cause of hypoparathyroidism is iatrogenic due to anterior neck surgery. In recent years it was documented that vitamin D insufficiency is widespread.Aim: To investigate the cause of hypocalcemia in thyroidectomized patients with PTH within the reference range.Methods: Retrospective review of clinical re...

Introduction: Treatment of hyperthyroidism in older adults is crucial to reduce its morbidity and mortality. Radioactive iodine has been widely used in this age group due to its efficacy, safety and cost-effectiveness.Aim: To determine the efficacy of 131I for treatment of hyperthyroidism in the elderly.Methods: Retrospective study of 86 hyperthyroid patients aged ≥65 years who performed radioiodine therapy. We eva...